Application Of Carboxymethylcellulose As A Carrier Of Medical Preparations For The Burn Wounds Treatment

Abstract

Non-invasive gel-based preparations for the treatment of purulent and burn wounds are of particular interest in medicine and pharmacology nowadays. From a technological point of view, they are hydrophilic components that swell in water forming colloidal solutions with variable consistency. Such solutions include carboxymethylcellulose (CMC) gels. This compound has significant advantages compared to fat-based ointments, namely: high osmolarity, facilitation of sloughing and wound cleansing, and adsorption of discharge from wound. Such systems have necessary characteristics for use in medicine: low toxicity, solubility in water, resistanсe to the environmental factors. They show buffering action on addition of electrolytes and almost unsusceptible to microbial contamination. At the same time, carboxymethylcellulose is hypoallergic, does not provoke skin reactions, and the raw materials for CMC production are inexpensive which makes them cost effective.